Question
We have a SYS-220U-TNR that's having issue with some nvme drives keep dropping off from PCIe bus.  Is there any troubleshooting tips and solution to address this issue?
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Answer
Try move the nvme drives that are dropping to other slots.  
Add this into grub and rebuild the grub file
"nvme_core.default_ps_max_latency_us=0 pcie_aspm=off pcie_port_pm=off raid=noautodetect pci=pcie_bus_perf

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